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FLASH GENE
Symbol AQP1 contributors: mct/npt - updated : 11-02-2014
HGNC name aquaporin 1 (Colton blood group)
HGNC id 633
ASSOCIATED DISORDERS
corresponding disease(s) CO
related resource Blood Group Antigen Mutation Database
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
alteration of its expression in fetal membranes and placenta may be important in the pathophysiology of isolated oligohydramnios
constitutional     --low  
in ischemia, hypoxia and cardioplegia
constitutional     --over  
in the cerebrospinal fluid of bacterial meningitis patients
constitutional     --low  
in the alveolar microvessels may act as a compensatory mechanism to protect against formation of excessive pulmonary edema in chronic heart failure (CHF
tumoral     --over  
may play an important role in the ovarian carcinogenesis, progression, and ascites formation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerbrainglioma/neuroblstoma
sSuppression of AQP1 expression could be a potential means of reducing invasion of glioma cells
neurosensorialear 
appear to be important for the development of novel drug therapies for Meniere's disease and related disorders
miscelleaneouspain 
novel target for pain management
cancerlung 
potential role of AQP1 or AQP4 as novel therapeutic targets for the management of lung cancer
miscelleaneouspain 
potential therapeutic target for migraine with aura
ANIMAL & CELL MODELS