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FLASH GENE
Symbol NRG1 contributors: mct/shn - updated : 03-08-2015
HGNC name neuregulin 1
HGNC id 7997
ANIMAL & CELL MODELS
  • in cysteine-rich domain-NRG-1-/-mice, peripheral projections defasciculated and displayed aberrant branching patterns within their targets (
  • knock-down of nrg1 caused near total loss of olig2-positive cerebellar neurones, but caused no apparent loss of spinal motor neurones (
  • misexpression of human NRG1 type III in zebrafish transgenic embryos results in ectopic Schwann cell migration, allowing them to aberrantly enter the central nervous system
  • in murine juvenile testes Ra and Fsh induced meiosis indirectly through Sertoli cells when Nrg1 and Nrg3 were upregulated, as Nrg1 amplified itself and Nrg3