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FLASH GENE

Symbol

NRG1

contributors: mct/shn - updated : 03-08-2015

HGNC name	neuregulin 1
HGNC id	7997

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCZD6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion       chimeric protein gamma heregulin (ERBG) by fusion with STIP1 (5'-STIP1-NRG1-3') in translocation t(8;11) (p12;q13 constitutional     --low   in amyotrophic lateral sclerosis and Parkinson's disease, in cerebral fluid constitutional     --over   in Alzheimer's disease tumoral         silenced by methylation in breast cancers

Susceptibility

to schizophrenia ( to late onset Alzheimer's disease with psychoses to Hirschsprung's disease

Variant & Polymorphism SNP	increasing the risk of late onset Alzheimer's disease families with psychoses
	SNP increasing the risk of schizophrenia
	interaction between variants in NRG1 and ERBB4 might contribute to susceptibility for schizophrenia
	SNP increasing the risk of Hirschsprung's disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired heart failure potential use of NRG1s as novel therapy for heart failure respiratory lung   may represent a novel therapeutic target for mucus hypersecretion in respiratory diseases

ANIMAL & CELL MODELS

	in cysteine-rich domain-NRG-1-/-mice, peripheral projections defasciculated and displayed aberrant branching patterns within their targets (
	knock-down of nrg1 caused near total loss of olig2-positive cerebellar neurones, but caused no apparent loss of spinal motor neurones (
	misexpression of human NRG1 type III in zebrafish transgenic embryos results in ectopic Schwann cell migration, allowing them to aberrantly enter the central nervous system
	in murine juvenile testes Ra and Fsh induced meiosis indirectly through Sertoli cells when Nrg1 and Nrg3 were upregulated, as Nrg1 amplified itself and Nrg3