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FLASH GENE
Symbol DPP6 contributors: mct/npt - updated : 23-04-2009
HGNC name dipeptidylpeptidase 6
HGNC id 3010
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an additional serine near the "active" site
    • mono polymer dimer
    HOMOLOGY
    intraspecies homolog to dipeptidylpeptidase
    homolog to the related protein DPP-IV
    Homologene
    FAMILY
  • peptidase family S9B
  • dipeptidyl aminopeptidase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in the physiological processes of brain function
  • essential component of the native cardiac I(to) channel complex in heart (Radicke 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • putative component of the transient outward current in the heart (Alders 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD33
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Idiopathic Ventricular Fibrillation (see VFI1) (Alders 2009)
    Susceptibility to amyotrophic lateral sclerosis
    Variant & Polymorphism SNP strongly associated with susceptibility to amyotrophic lateral sclerosis (Dupre 20098)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS