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FLASH GENE
Symbol CEBPD contributors: mct - updated : 11-02-2015
HGNC name CCAAT/enhancer binding protein (C/EBP), delta
HGNC id 1835
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) protein
    • HOMOLOGY
    interspecies homolog to murine Cebpd
    Homologene
    FAMILY
  • bzip family
  • CUG-BP and ETR-3-like factor (CELF) family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text predominantly nuclear
    basic FUNCTION
  • CCAAT enhancer binding protein delta (C/EBP)
  • inducing conjointly with CEBPD the induction of CEBPB and PPARG, required for adipocyte differentiation
  • STAT3 target and crucial mediator of pro-apoptotic gene expression events in mammary epithelial cells
  • tumor suppressor because that induces growth arrest involved in differentiation and plays a crucial role as a regulator of pro-apoptotic gene expression
  • are potentially key players in the integrated gene expression program involved in postnatal cardiac remodeling and maturation
  • plays a role in genome maintenance or DNA-repair pathways
  • augments cell survival after DNA damage from interstrand cross-linkers by facilitating nuclear import of FANCD2
  • role of endogenous CEBPD in nuclear translocation of FANCD2
  • CEBPD plays an essential role in HMDB (1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione)-mediated apoptosis of cancer cells
  • necessary for efficient tumour metastasis
  • enhances MTOR/AKT/S6K1 signalling and augments translation and activity of hypoxia-inducible factor-1á (HIF1A), which is necessary for hypoxia adaptation
  • role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of Alzheimer disease pathogenesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacting with STAT3
  • MYC, ZBTB17 and MAX are associated with the CEBPD promoter in proliferating cells, when CEBPD expression is repressed
  • interacts with FANCD2 (CEBPD mediates the indirect association of FANCD2 with IPO4 through its interaction with both of these proteins via separate domains)
  • inflammatory marker pentraxin-3 (PTX3) is a CEBPD target in astrocytes
  • RRAD inhibits CTGF expression through binding with CEBPD, thus regulating ECM (extracellular matrix) production in the heart
  • dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of CEBPB and CEBPD and direct transcriptional activation of PPARG2 and CEBPA during adipocyte differentiation
    • cell & other
    REGULATION
    repressed by MYC, that represses CEBPD expression by associating with the CEBPD proximal promoter as a transient component of a repressive complex that includes MAX and ZBTB17
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    during heart development
    tumoral       loss of function
    in cervical cancer and hepatocellular carcinoma
    constitutional       gain of function
    in the astrocytes of Alzheimer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    HMDB kills cancer cells through activation of CEBPD pathways and potentially can serve as a superior chemotherapeutic agent with limited potential for adverse side effects
    ANIMAL & CELL MODELS