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FLASH GENE
Symbol DEFA4 contributors: mct - updated : 21-01-2015
HGNC name defensin, alpha 4, corticostatin
HGNC id 2763
Location 8p23.1      Physical location : 6.793.344 - 6.795.786
Synonym name
  • corticostatin (antineutrophil antibacterial peptide-4)
  • defensin, alpha 4, preproprotein
  • cryptdin-4
  • Synonym symbol(s) CSI, HNP4, HP-4, HP4, DEF4, Crp4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.44 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 542 - 97 - 2006 17088326
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    six disulfide-linked cysteines
    HOMOLOGY
    Homologene
    FAMILY alpha-defensin family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text from azurophil granules
    basic FUNCTION
  • antineutrophil antibacterial peptide, involved in oxygen independent phagocytosis of Gram+, Gram- bacteria, many fungi, some viruses
  • function of the conserved salt bridge in DEFA4 is not linked to bactericidal activity or proteolytic stability of the mature peptide
  • antimicrobial and chemotactic activity of DEFA4 is somewhat comparable to that of other human neutrophil defensins
  • had no intrinsic transcriptional activity, but exhibited adaptor function, because it acted synergistically with serum response factor (SRF) and GATA6 to activate the smooth muscle (SM)-alpha-actin promoter
  • translocate cooperatively across phospholipid bilayers
  • its translocation has implications for its antimicrobial activity as internalized peptide would be available to attack intracellular targets
  • has likely selective bactericidal activities against intestinal microbiota and the activities are dependent on the disulfide bonds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS