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FLASH GENE
Symbol RPA3 contributors: mct/pgu - updated : 05-03-2012
HGNC name replication protein A3, 14kDa
HGNC id 10291
Location 7p22      Physical location : 7.676.576 - 7.758.238
Genatlas name G replication protein A, subunit 3
Synonym name
  • RF-A protein 3
  • RP-A p14
  • replication protein A 14 kDa subunit
  • Synonym symbol(s) REPA3, RPA14
    DNA
    TYPE functioning gene
    STRUCTURE 81.66 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    PP35 7q22-q31 protein similar to E.coli yhdg and R. capsulatus nifR3 BCAP29 7q22-q31 B-cell receptor-associated protein 29 LOC253933 7p22.2 similar to olfactory receptor MOR145-1 C1GALT1 7p14-p13 similar to olfactory receptor MOR145-1 LOC155340 7p22.2 similar to unc-93 homolog B1; unc93 (C.elegans) homolog B; unc-93 related protein LOC392000 7 hypothetical gene supported by AK122996 SLC26A4 7q31.1 solute carrier family 26, member 4 LOC392001 7 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC346364 7p22.2 similar to hypothetical protein FLJ10661 LOC392630 7 similar to matrilin 2 precursor CBLL1 7q22.3 Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1 SLC26A3 7q33 solute carrier family 26, member 3 CACNA2D1 7q21.3-q22.1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 LOC340267 7p22.1 similar to Matn2-prov protein LOC346365 7p22.2 similar to vav-1 interacting Kruppel-like protein isoform a DLD 7q31-q32 dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex) LAMB1 7q22.1 laminin, beta 1 FLJ20323 7p22-p21 hypothetical protein FLJ20323 C1GALT1 7p14-p13 hypothetical protein FLJ20323 RPA3 7p22 replication protein A3, 14kDa LOC392775 7 similar to laminin beta-4 chain precursor LOC285929 7p22.1 similar to matrilin 2 precursor NRCAM 7q31.1-q31.2 neuronal cell adhesion molecule LOC389462 7 similar to Matn2-prov protein LOC392868 7 similar to cyclin B2 FLJ20323 7p22-p21 hypothetical protein FLJ20323 GLCCI1 7p22.2 glucocorticoid induced transcript 1 RPA3 7p22 replication protein A3, 14kDa ICA1 7p22 islet cell autoantigen 1, 69kDa LOC392776 7 similar to calcium-independent phospholipase A2 THAP5 7q22.3 THAP domain containing 5 DNAJB9 14q24.2-q24.3 DnaJ (Hsp40) homolog, subfamily B, member 9 LOC392742 7 similar to [Segment 2 of 2] Piccolo protein (Aczonin) LOC392002 7 similar to cyclin B2 GLCCI1 7p22.2 glucocorticoid induced transcript 1 NXPH1 7p22 neurexophilin 1 ICA1 7p22 islet cell autoantigen 1, 69kDa LOC392777 7 LOC392777 LOC392743 7 similar to [Segment 1 of 2] Piccolo protein (Aczonin) AUTS2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1613 13.4 121 - 2009 19010961
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
     brain    
     braindiencephalonhypothalamus  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to yeast Rfa3
    ortholog to Schizosaccharomyces pombe Ssb3
    Homologene
    FAMILY replication protein A family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in DNA replication, repair, and recombination
  • with RPA1, and RPA2, plays essential roles in DNA transactions
  • single-stranded (ss) DNA-binding protein highly conserved in eukaryotes and playing essential roles in many aspects of nucleic acid metabolism, including replication, recombination, DNA repair and telomere maintenance
  • playing potentially a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair, nucleotide excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a trimeric single strand binding protein,the replication protein A complex,involved in replication,homologous recombination and nucleotide excision repair
  • INTERACTION
    DNA interacting directly with ssDNA
    RNA
    small molecule
    protein
  • interacts with the specific proteins among those that play roles in the regulation of the replication fork progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS