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FLASH GENE

Symbol

RPA3

contributors: mct/pgu - updated : 05-03-2012

HGNC name	replication protein A3, 14kDa
HGNC id	10291

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p22      Physical location : 7.676.576 - 7.758.238
Genatlas name	G replication protein A, subunit 3
Synonym name	RF-A protein 3
	RP-A p14
	replication protein A 14 kDa subunit
Synonym symbol(s)	REPA3, RPA14

DNA

TYPE	functioning gene
STRUCTURE	81.66 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002947 8 - 1613 13.4 121 - 2009 19010961

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus       brain           brain diencephalon hypothalamus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to yeast Rfa3
	ortholog to Schizosaccharomyces pombe Ssb3

Homologene

FAMILY

replication protein A family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	playing a role in DNA replication, repair, and recombination
	with RPA1, and RPA2, plays essential roles in DNA transactions
	single-stranded (ss) DNA-binding protein highly conserved in eukaryotes and playing essential roles in many aspects of nucleic acid metabolism, including replication, recombination, DNA repair and telomere maintenance
	playing potentially a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase

CELLULAR PROCESS	nucleotide, replication
	nucleotide, repair, nucleotide excision repair
	nucleotide, repair, recombination

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a trimeric single strand binding protein,the replication protein A complex,involved in replication,homologous recombination and nucleotide excision repair

INTERACTION

DNA	interacting directly with ssDNA

RNA

small molecule

protein

interacts with the specific proteins among those that play roles in the regulation of the replication fork progression

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS