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FLASH GENE
Symbol HSD11B1 contributors: mct - updated : 17-03-2009
HGNC name hydroxysteroid (11-beta) dehydrogenase 1
HGNC id 5208
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Hsd11b1
homolog to C.elegans T25G12.7
Homologene
FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxysteroid dehydrogenase 11-beta 1, NADP dependent
  • regulates glucocorticoid action at the pre-receptor stage by converting cortisone to cortisol
  • playing a role in cell-to-cell signaling
  • regenerates active cortisol from inactive cortisone
  • bi-directional, vascular 11beta-HSD1 favors reactivation (reductase) over the deactivation (dehydrogenase) reaction, impairing Gc (glucocorticoids) deactivation (correlated with lower vascular resistance)
  • implicated in the pathogenesis of central obesity and metabolic syndrome
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , lipid/lipoprotein
    signaling
    glucocorticoid metabolism in liver, steroid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • NADP
    • protein with COX2 (co-localizes with COX2 in proximal tubule cells)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CRD1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in adipose tissues from obese
    constitutional     --over  
    linked to increasing age and alcohol intake
    Susceptibility to obesity
    Variant & Polymorphism other 11beta-HSD1 activity increases with age, and is reduced in obese boys
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS