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FLASH GENE

Symbol

PPP2CB

contributors: mct - updated : 22-12-2021

HGNC name	protein phosphatase 2, catalytic subunit, beta isozyme
HGNC id	9300

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	27.23 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001009552 7 - 1987 NP_001009552 35 309 - 1991 1846293 a 7 exons variant containing exon 1b (including variant 1 exons 1 & 2) longer transcript encoding for the same product as variant 1

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       moderately Hearing/Equilibrium ear inner cochlea   highly Nervous brain       moderately   nerve cranial nerve     highly Urinary bladder       moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective bone     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

catalytic subunit containing a C terminal carboxyl group methylated by carboxyl methyltransferase

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to rattus Ppp2cb (100.00 pc)
	homolog to murine Ppp2cb (100.00 pc)

Homologene

FAMILY	PPP phosphatase family
	PP-1 subfamily

CATEGORY

enzyme , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus

basic FUNCTION	protein phosphatase 2A, catalytic subunit
	potential modulation of phosphorylase-b-kinase, casein kinase 2 and others
	function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007)
	act as a negative regulator of NFKB1-mediated inflammatory signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complexing with a 65 kDa regulatory subunit

INTERACTION

DNA

RNA

small molecule	metal binding, other,
	Fe
	Mn

protein	IGBP1
	PME1
	PRKACA destabilizes PP2CB upon inflammatory stimuli via phosphorylation of Ser-195 in PP2CB
	PPP2CB, a catalytic subunit of protein phosphatase 2A, could interact directly with GADD45A

cell & other

REGULATION

Other

negatively regulated by ISG15 conjugation

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
Therapy target

ANIMAL & CELL MODELS