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FLASH GENE
Symbol PPP2CB contributors: mct - updated : 22-12-2021
HGNC name protein phosphatase 2, catalytic subunit, beta isozyme
HGNC id 9300
Location 8p12      Physical location : 30.643.126 - 30.670.352
Synonym name
  • protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
  • serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform
    • Synonym symbol(s) PP2CB, PP2Abeta
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 27.23 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1987 35 309 - 1991 1846293
  • a 7 exons variant
  • containing exon 1b (including variant 1 exons 1 & 2)
  • longer transcript
  • encoding for the same product as variant 1
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   moderately
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain   moderately
     nervecranial nerve  highly
    Urinarybladder   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  moderately
    Connectivebone  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • catalytic subunit containing a C terminal carboxyl group methylated by carboxyl methyltransferase
    • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Ppp2cb (100.00 pc)
    homolog to murine Ppp2cb (100.00 pc)
    Homologene
    FAMILY
  • PPP phosphatase family
  • PP-1 subfamily
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    basic FUNCTION
  • protein phosphatase 2A, catalytic subunit
  • potential modulation of phosphorylase-b-kinase, casein kinase 2 and others
  • function as tumor suppressor protein, and important physiological regulator of cell growth and of cellular stress signaling (Lammers 2007)
  • act as a negative regulator of NFKB1-mediated inflammatory signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with a 65 kDa regulatory subunit
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Fe
  • Mn
    • protein
  • IGBP1
  • PME1
  • PRKACA destabilizes PP2CB upon inflammatory stimuli via phosphorylation of Ser-195 in PP2CB
  • PPP2CB, a catalytic subunit of protein phosphatase 2A, could interact directly with GADD45A
    • cell & other
    REGULATION
    Other negatively regulated by ISG15 conjugation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
    Therapy target
    ANIMAL & CELL MODELS