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FLASH GENE
Symbol MED22 contributors: mct - updated : 27-08-2012
HGNC name mediator complex subunit 22
HGNC id 11477
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Surf5
homolog to Drosophila EG:BACR7A4.6
homolog to C.elegans E01G6.2
Homologene
FAMILY SURF5 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of essential MED11/22 heterodimer (forms a conserved four-helix bundle domain with C-term
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS