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FLASH GENE
Symbol MED22 contributors: mct - updated : 27-08-2012
HGNC name mediator complex subunit 22
HGNC id 11477
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 thymus   highly
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Surf5
homolog to Drosophila EG:BACR7A4.6
homolog to C.elegans E01G6.2
Homologene
FAMILY SURF5 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of essential MED11/22 heterodimer (forms a conserved four-helix bundle domain with C-term
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS