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FLASH GENE

Symbol

MED22

contributors: mct - updated : 27-08-2012

HGNC name	mediator complex subunit 22
HGNC id	11477

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_133640 5 splicing 1448 NP_598395 22.2 200 - 2004 15175163 using alternate splice sites on exons 4 and 5 compared to variant a NM_181491 4 splicing 3887 NP_852468 - 140 - 2004 15175163

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   thymus       highly Respiratory respiratory tract trachea     highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to murine Surf5
	homolog to Drosophila EG:BACR7A4.6
	homolog to C.elegans E01G6.2

Homologene

FAMILY

SURF5 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

part of essential MED11/22 heterodimer (forms a conserved four-helix bundle domain with C-term

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS