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FLASH GENE
Symbol MED22 contributors: mct - updated : 27-08-2012
HGNC name mediator complex subunit 22
HGNC id 11477
DNA
TYPE like-sequence
SPECIAL FEATURE component of a cluster, head to head, opposite orientation
text
  • see SURF@
  • oriented in a head-to-head fashion with RPL7A (SURF3) and sharing a bidirectional promoter
    • STRUCTURE 7.21 kb     4 Exon(s)
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked Y status confirmed
    Map see SURF@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 1448 22.2 200 - 2004 15175163
    using alternate splice sites on exons 4 and 5 compared to variant a
    4 splicing 3887 - 140 - 2004 15175163
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Surf5
    homolog to Drosophila EG:BACR7A4.6
    homolog to C.elegans E01G6.2
    Homologene
    FAMILY SURF5 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of essential MED11/22 heterodimer (forms a conserved four-helix bundle domain with C-term
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS