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FLASH GENE
Symbol ADCY8 contributors: mct - updated : 27-09-2010
HGNC name adenylate cyclase 8 (brain)
HGNC id 239
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text abundant during development, with diffuse and increasing expression in the hippocampus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 1-5-8-14 motif at the N terminus, and N-terminal CaM binding domain that has a role in recruiting CALM1 and this recruitment is essential to permit stimulation by Ca2+
  • two homologous domains
  • first 77 AAs contain a helical calmodulin binding domain, located between residues 34 and 51
  • two CaM-binding domains,
  • an IQ-like motif (IQlm) at the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Adcy8
    Homologene
    FAMILY
  • adenylyl cyclase class-4/guanylil cyclase family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • membrane-bound, calcium inhibitable adenyl cyclase involved in learning, memory, drug dependance
  • with ADCY1, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory
  • plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity
  • Ca2+-stimulable adenylate cyclase, interacting with an AKAP and role for AKAP5 in the attenuation of Ca2+-dependent ADCY8 activity
  • essential component of a signaling pathway that opposes repellent signaling, and helps regulate retinal sensitivity to midline guidance cues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with AKAP5 mediates inhibition of Ca2+-dependent cAMP production
  • AKAP5 directly bind to adenylyl cyclase type 8 (ADCY8) and regulate its responsiveness to store-operated Ca2+ entry (SOCE)
    • cell & other
    REGULATION
    activated by Ca(2+)/calmodulin (CaM), and having discrete neuronal functions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS