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FLASH GENE

Symbol

ADCY8

contributors: mct - updated : 27-09-2010

HGNC name	adenylate cyclase 8 (brain)
HGNC id	239

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001115 18 - 4145 NP_001106 140.1 1251 - PMID: 8076676

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	abundant during development, with diffuse and increasing expression in the hippocampus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 1-5-8-14 motif at the N terminus, and N-terminal CaM binding domain that has a role in recruiting CALM1 and this recruitment is essential to permit stimulation by Ca2+
	two homologous domains
	first 77 AAs contain a helical calmodulin binding domain, located between residues 34 and 51
	two CaM-binding domains,
	an IQ-like motif (IQlm) at the C terminus

HOMOLOGY

interspecies

ortholog to murine Adcy8

Homologene

FAMILY

adenylyl cyclase class-4/guanylil cyclase family

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	membrane-bound, calcium inhibitable adenyl cyclase involved in learning, memory, drug dependance
	with ADCY1, are the only cyclases stimulated by calcium and calmodulin, making them uniquely poised to regulate neuronal development and neuronal processes such as learning and memory
	plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity
	Ca2+-stimulable adenylate cyclase, interacting with an AKAP and role for AKAP5 in the attenuation of Ca2+-dependent ADCY8 activity
	essential component of a signaling pathway that opposes repellent signaling, and helps regulate retinal sensitivity to midline guidance cues

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

purine/pyrimidine

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction with AKAP5 mediates inhibition of Ca2+-dependent cAMP production
	AKAP5 directly bind to adenylyl cyclase type 8 (ADCY8) and regulate its responsiveness to store-operated Ca2+ entry (SOCE)

cell & other

REGULATION

activated by

Ca(2+)/calmodulin (CaM), and having discrete neuronal functions

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS