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FLASH GENE

Symbol

NFYB

contributors: mct - updated : 18-03-2015

HGNC name	nuclear transcription factor Y, beta
HGNC id	7805

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a N terminal A domain,a highly conserved central B domain involved in DNA binding,a C terminal C domain rich in glutamine and acidic residues involved in protein-protein interactions

HOMOLOGY

intraspecies

homolog to H2B

Homologene

FAMILY

cbf-a subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	essential for expression of the proapoptotic BCL2L11 gene in sympathetic neurons

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forming a trimeric complex with NFYB and NFYC

INTERACTION

DNA	binding to the CCAAT and the inverted CCAT-box,Y-box (ATGG) motifs in a variety of promoters

RNA

small molecule

protein	interacting with SARS2 (NFYA, NFYB, NFYC influences directionality of transcription from the bidirectional MRPS12/SARS2 promoter)
	NFYA, NFYB, NFYC, cooperates with FOXO3 to recruit EP300 to the BCL2L11 promoter to form a stable multi-protein/DNA complex that activates BCL2L11 transcription after survival factor withdrawal
	NFYA, NFYB, NFYC can act as a transcriptional activator of ABCB4
	NFYA, NFYB, NFYC and YY1 are important for the basal transcription of PCYT2 and NFY is involved in the inhibitory effects of 25-HC on PCYT2 transcription

cell & other

REGULATION

activated by

ATF6

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function impaired cells from exiting G2/M, but did not interfere with S-phase progression (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS