Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HOXA2 contributors: mct - updated : 16-06-2021
HGNC name homeobox A2
HGNC id 5103
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
    • HOMOLOGY
    interspecies homolog to murine Hox-1.11
    homolog to Drosophila pb
    Homologene
    FAMILY
  • ANTP homeobox family
  • proboscipedia subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development
  • displays an anti-chondrogenic activity that is distinct from its patterning function
  • DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TLX1, SIX2 (loss-of-function of TLX1 leads to loss of SIX2 expression and loss-of-function of HOXA2 leads to expanded SIX2 expression)
  • MEOX1 can specifically bind the DNA sequences recognized by HOXA2 on its functional target genes
  • HOXA2 binds to PCP4 chromatin and regulates PCP4 expression in the second arch
  • UBAC1 regulates HOXA2 by promoting its relocation to the cytoplasm
  • HOXA2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation
  • HOXA2 may regulate palate development by inhibiting osteogenic differentiation of palatal mesenchyme via modulating BMP signaling
  • PPP1CB and UBAC1 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm
    • cell & other
    REGULATION
    repressed by CHD8 that represses ATRA mediated HOXA2 gene expression
    ASSOCIATED DISORDERS
    corresponding disease(s) MCROT1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Persistent Hoxa2 expression in chondrogenic cells resulted in overall chondrodysplasia with delayed cartilage hypertrophy, mineralization, and ossification but without proliferation defects (Massip 2007)