Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

HOXA2

contributors: mct - updated : 16-06-2021

HGNC name	homeobox A2
HGNC id	5103

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	2.42 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map

see HOXA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006735 2 - 1791 NP_006726 - 376 - 2003 12853948

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine adrenal gland       highly Lymphoid/Immune lymph node       highly Reproductive male system prostate       Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

helix-turn-helix, DNA binding domain

HOMOLOGY

interspecies	homolog to murine Hox-1.11
	homolog to Drosophila pb

Homologene

FAMILY	ANTP homeobox family
	proboscipedia subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development
	displays an anti-chondrogenic activity that is distinct from its patterning function
	DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with TLX1, SIX2 (loss-of-function of TLX1 leads to loss of SIX2 expression and loss-of-function of HOXA2 leads to expanded SIX2 expression)
	MEOX1 can specifically bind the DNA sequences recognized by HOXA2 on its functional target genes
	HOXA2 binds to PCP4 chromatin and regulates PCP4 expression in the second arch
	UBAC1 regulates HOXA2 by promoting its relocation to the cytoplasm
	HOXA2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation
	HOXA2 may regulate palate development by inhibiting osteogenic differentiation of palatal mesenchyme via modulating BMP signaling
	PPP1CB and UBAC1 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm

cell & other

REGULATION

repressed by

CHD8 that represses ATRA mediated HOXA2 gene expression

ASSOCIATED DISORDERS

corresponding disease(s)

MCROT1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Persistent Hoxa2 expression in chondrogenic cells resulted in overall chondrodysplasia with delayed cartilage hypertrophy, mineralization, and ossification but without proliferation defects (Massip 2007)