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FLASH GENE

Symbol

PTGS1

contributors: mct - updated : 17-07-2006

HGNC name	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
HGNC id	9604

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site

mono polymer

homomer , monomer , dimer

HOMOLOGY

Homologene

FAMILY

Kernel group, lipocalin family

CATEGORY

enzyme , immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	prostaglandin G/H synthase, acting first as a dioxygenase, then as a peroxidase, potent mediator of inflammation
	plays a previously unrecognized role in neuroinflammatory damage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	other,
	binding 1 heme B (iron-protoporphyrin IX) group per molecule

protein

cell & other

target of nonsteroidal anti- inflammatory drugs

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     augments prostacyclin and retards atherogenesis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS