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FLASH GENE
Symbol PTGS1 contributors: mct - updated : 17-07-2006
HGNC name prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
HGNC id 9604
Location 9q32-q33.3      Physical location : 125.133.228 - 125.157.981
Synonym name cyclooxygenase 1
Synonym symbol(s) PGGHS, PGHS1, COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1
EC.number 1.14.99.1
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence
text structure 5'end of mRNA represses translation and could delay the synthesis of PTGS 1 enzyme (Bunimov 2007)
MAPPING cloned Y linked   status confirmed
Physical map
STOM 9q34.1 stomatin a1/3GTP 9q34.11 alpha-1,3-galactosyltransferase pseudogene DAB2IP 9q33.1-q33.3 DAB2 interacting protein LOC158135 9q34.11 similar to H23L24.3.p NDUFA8 9q32.4-q34.41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa FLJ46909 9q34.11 FLJ46909 protein LHX6 9q34.11 LIM homeobox 6 MGC2734 MRRF 9q33-q34.1 mitochondrial ribosome recycling factor PTGS1 9q32-q33.3 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) LOC347168 9q34.11 similar to Olfactory receptor 1J1 OR1J5 9q34.11 olfactory receptor, family 1, subfamily J, member 5 OR1J4 9q34.2 olfactory receptor, family 1, subfamily J, member 4 LOC138883 9q34.11 similar to Olfactory receptor 1N3 LOC138882 9q34.11 similar to Olfactory receptor 1N2 LOC138881 9q34.11 similar to Olfactory receptor 1L8 LOC392389 9 similar to G protein-coupled receptor homolog clone H8 LOC158131 9q34.11 similar to Olfactory receptor 1Q1 (Olfactory receptor TPCR106) (Olfactory receptor 9-A) (OR9-A) (OST226) LOC347169 9q34.11 similar to Olfactory receptor 1B1 (Olfactory receptor 9-B) (OR9-B) LOC158130 9q34.11 similar to tousled-like kinase 1; serine threonine protein kinase LOC254973 9q34.11 similar to Olfactory receptor 1L4 (Olfactory receptor 9-E) (OR9-E) (OST046) LOC392390 9 similar to Olfactory receptor 1L6 LOC389789 9 similar to hypothetical protein LOC348235 LOC392391 9 similar to Olfactory receptor 5C1 (Olfactory receptor 9-F) (OR9-F) LOC392392 9 similar to Olfactory receptor 1K1 PDCL 9q12-q13 phosducin-like MNAB 9q34 phosducin-like ZNF482 9q34.11 zinc finger protein 482 ZNF481 9 zinc finger protein 481 GAPCENA 9q33.1-q33.3 zinc finger protein 481 GPR21 9q33 G protein-coupled receptor 21 C9orf45 9q34.11 chromosome 9 open reading frame 45 STRBP 9q34.11 spermatid perinuclear RNA binding protein FLJ38464 9q34.11 hypothetical protein FLJ38464 KIAA1608 9q34.11 KIAA1608
RNA
TRANSCRIPTS type messenger
text two transcripts
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 4982 - 562 bladder, appendix Bhandari
- splicing 5093 - - colon, bone marrow, uterus, prostate, stomach Bhandari
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 mouthtongue  highly
 stomach    
Reproductivefemale systemuteruscervix highly
 male systemprostate  highly
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site
  • mono polymer homomer , monomer , dimer
    HOMOLOGY
    Homologene
    FAMILY Kernel group, lipocalin family
    CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • prostaglandin G/H synthase, acting first as a dioxygenase, then as a peroxidase, potent mediator of inflammation
  • plays a previously unrecognized role in neuroinflammatory damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    binding 1 heme B (iron-protoporphyrin IX) group per molecule
    protein
    cell & other target of nonsteroidal anti- inflammatory drugs
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    augments prostacyclin and retards atherogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS