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FLASH GENE

Symbol

PTGS1

contributors: mct - updated : 17-07-2006

HGNC name	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
HGNC id	9604

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q32-q33.3      Physical location : 125.133.228 - 125.157.981
Synonym name	cyclooxygenase 1
Synonym symbol(s)	PGGHS, PGHS1, COX1, COX3, PCOX1, PGG/HS, PGHS-1, PGHS1, PHS1
EC.number	1.14.99.1

DNA

TYPE	functioning gene
STRUCTURE	24.00 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence
text structure	5'end of mRNA represses translation and could delay the synthesis of PTGS 1 enzyme (Bunimov 2007)

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	two transcripts

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed COX1 V2 - splicing 4982 - 562 bladder, appendix Bhandari COX1 V1 - splicing 5093 - - colon, bone marrow, uterus, prostate, stomach Bhandari

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       mouth tongue     highly   stomach         Reproductive female system uterus cervix   highly   male system prostate     highly Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site

mono polymer

homomer , monomer , dimer

HOMOLOGY

Homologene

FAMILY

Kernel group, lipocalin family

CATEGORY

enzyme , immunity/defense

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	prostaglandin G/H synthase, acting first as a dioxygenase, then as a peroxidase, potent mediator of inflammation
	plays a previously unrecognized role in neuroinflammatory damage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	other,
	binding 1 heme B (iron-protoporphyrin IX) group per molecule

protein

cell & other

target of nonsteroidal anti- inflammatory drugs

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     augments prostacyclin and retards atherogenesis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS