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FLASH GENE
Symbol CHRNB3 contributors: mct - updated : 24-08-2010
HGNC name cholinergic receptor, nicotinic, beta polypeptide 3
HGNC id 1963
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • four transmembrane segments (4TM) with the M2 domain comprising the cation-selective pore
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Chrnb3
    Homologene
    FAMILY
  • cholinergic receptor family
  • ligand-gated ionic channel (tc 1.a.9) family
    • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • cholinergic receptor,nicotinic
  • ligand gated ion channel
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to heavy alcohol use
  • to tobacco dependence
    • Variant & Polymorphism SNP
  • rs13280604 associated with a composite of the alcohol phenotypes (Hoft 2009)
  • SNPs in CHRNB3 were found to be associated to tobacco dependence
  • sequence variants associated with smoking behavior (Thorgeirsson 2010)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS