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FLASH GENE

Symbol

IFNB1

contributors: mct - updated : 26-03-2020

HGNC name	interferon, beta 1, fibroblast
HGNC id	5434

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in dermatomyositis and polymyositis constitutional     --low   most lung cells from stable Chronic Obstructive Pulmonary Disease (COPD) patients show a constitutive decreased expression of IFNB1, IRF7, DDX58 and IFIH1, suggesting that this deficiency is the main cause of their acute viral exacerbations

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune multiple sclerosis major disease-modifying agent used for the treatment of multiple sclerosis (MS)

ANIMAL & CELL MODELS

	overexpression of Ifnb1 in the CNS of adult wild-type mice, but not of mice lacking IFN-I receptor on their microglia, induces an ageing-like transcriptional microglial signature, and impairs cognitive performance
	Ifnb mutant mice is a model for sporadic Lewy body and Parkinson's disease dementia