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FLASH GENE
Symbol GSR contributors: - updated : 10-05-2005
HGNC name glutathione reductase
HGNC id 4623
Corresponding disease
GSR hemolytic crisis
Location 8p21.1      Physical location : 30.535.581 - 30.585.486
Synonym symbol(s) GSHR
EC.number 1.8.1.7
DNA
TYPE functioning gene
STRUCTURE 48.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC389644 8 similar to 60S ribosomal protein L5 LOC346848 8p21.1 similar to 60S RIBOSOMAL PROTEIN L5 PNOC 8p21 prepronociceptin DKFZp434K1210 8p21.1 hypothetical protein DKFZp434K1210 PBF 8p21.1 papillomavirus regulatory factor PRF-1 FBXO16 8p21.1 F-box only protein 16 FZD3 8p21 frizzled homolog 3 (Drosophila) EXTL3 8p21 exostoses (multiple)-like 3 FLJ10871 8p21.1 hypothetical protein FLJ10871 FLJ21616 8p21.1 hypothetical protein FLJ21616 KIF13B 8p21-p12 kinesin family member 13B DUSP4 8p12-p11 dual specificity phosphatase 4 LOC392208 8 similar to Ac2-210 LOC389645 8 LOC389645 MAP2K1P1 8p21 mitogen-activated protein kinase kinase 1 pseudogene 1 MGC8721 8p12 hypothetical protein MGC8721 LEPROTL1 8p21.2-p21.1 leptin receptor overlapping transcript-like 1 DCTN6 8p12-p11 dynactin 6 LOC392209 8 similar to heat shock protein (hsp-2) LOC92755 8p21.1 hypothetical gene LOC92755 RBPMS 8p12-p11 RNA binding protein with multiple splicing GTF2E2 8p12-p11 general transcription factor IIE, polypeptide 2, beta 34kDa GSR 8p21.1 glutathione reductase D8S2298E 8p12-p11.2 Homo sapiens reproduction 8 (D8S2298E), mRNA. PPP2CB 8p12-p11.2 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform TEX15 8p12 testis expressed sequence 15 PURG 8p11 purine-rich element binding protein G WRN 8p12-p11.2 Werner syndrome LOC157589 8p12 similar to potassium channel tetramerisation domain containing 9 NRG1 8p21-p12 neuregulin 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Reproductivefemale systemplacenta   
 female systemuteruscervix  
 male systemprostate   
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated FlavoP
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • glutathione reductase (NADPH) FAD dependent
  • maintaining glutathione in the reduced state
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GSR
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS