| Symbol
| GSN
| contributors: mct/npt/pgu - updated : 06-05-2014
|
| HGNC name
| gelsolin (amyloidosis, Finnish type)
|
| HGNC id
| 4620
|
| corresponding disease(s)
|
CAAG
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
|
is highly expressed in murine and human hearts after myocardial infarction and is associated with progression of heart failure  | | tumoral
|
|
| --low
|
| |
in pancreatic cancer and enhanced targeting of gelsolin to the ubiquitin-proteasome pathway is an important contributing factor for this effect | | tumoral
|
|
| --low
|
| |
in breast cancer tissues and is linked with metastasis development and death in patients | | constitutional
|
|
|
| loss of function
| |
inactivation of gelsolin during sperm capacitation occurs by its binding to PIP(2) and tyrosine phosphorylation by SRC | |
Variant & Polymorphism
| 
| |
| Candidate gene
| for malignant pleural mesothelioma |
| Marker
| CSF-gelsolin level might reflect the alteration of gelsolin in brain tissue of epileptic patients and CSF-gelsolin seems to be a potential biomarker for epilepsy |
Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cardiovascular | aquired | heart failure | |
| inhibition of GSN may form a novel target for heart failure therapy |
| |
|
| GSN(-/-) mice have a surprisingly lower mortality, markedly reduced hypertrophy, smaller late infarct size, less interstitial fibrosis, and improved cardiac function when compared with GSN(+/+) mice | |
in Gsn(-/-) mice, emigration of newly generated cells from the subventricular zone into the olfactory bulb was slowed |