basic FUNCTION
| implicated in actin remodeling in growing and in apoptotic cells |
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can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed |
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with calponin are reported to play signaling roles in addition to their better-characterized actin-binding properties and it is possible that the GCC regulates both of these functions |
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calcium-regulated actin severing and capping protein, having biological role in cardiac remodeling |
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important contributor to heart failure progression through novel mechanisms of HIF-1alpha and DNase I activation and downregulation of antiapoptotic survival factors |
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required for macrophage recruitment during remyelination of the peripheral nervous system |
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plays a role in the actin polymerization complex of hair cell stereocilia |
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ACSL1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis |
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regulate dynamic actin filament organization by severing and capping |
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also regulates cell morphology, differentiation, movement, and apoptosis |