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FLASH GENE
Symbol GPT contributors: mct - updated : 22-12-2009
HGNC name glutamic-pyruvate transaminase (alanine aminotransferase)
HGNC id 4552
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
  • class-I pyridoxal-phosphate-dependent aminotransferase family
  • alanine aminotransferase subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text in hepatocytes, only localised to the cytosol and ER, with no detection in mitochondria
    basic FUNCTION
  • glutamic-pyruvate transaminase (alanine aminotransferase)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes mellitus and cardiovascular disease
    Variant & Polymorphism other significantly associated with an adverse metabolic and atherothrombotic risk profile
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS