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FLASH GENE

Symbol

GPT

contributors: mct - updated : 22-12-2009

HGNC name	glutamic-pyruvate transaminase (alanine aminotransferase)
HGNC id	4552

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.09 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005309 11 - 1896 NP_005300 - 496 - 2009 19360321

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive liver       highly Homo sapiens Nervous brain         Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac   moderately Homo sapiens Muscular striatum skeletal   highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY	class-I pyridoxal-phosphate-dependent aminotransferase family
	alanine aminotransferase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
text	in hepatocytes, only localised to the cytosol and ER, with no detection in mitochondria

basic FUNCTION

glutamic-pyruvate transaminase (alanine aminotransferase)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to type 2 diabetes mellitus and cardiovascular disease

Variant & Polymorphism other	significantly associated with an adverse metabolic and atherothrombotic risk profile

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS