SUBCELLULAR LOCALIZATION
| plasma membrane
|
| intracellular
|
|
| intracellular,cytoplasm,organelle,membrane
|
|
| intracellular,cytoplasm,organelle,endosome
|
|
| intracellular,cytoplasm,organelle,lysosome
|
|
| intracellular,cytoplasm,cytosolic
|
|
| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
|
| basic FUNCTION
| ATPase H+ transporting, non catalytic accessory protein, vacuolar proton pump 1 |
|
in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles  |
|
ATP6V0A1, ATP6V0A2 cooperatively regulate the acidification and transmitter uptake/storage of dense-core vesicles, whereas they might not be as critical for exocytosis |
|
transport protons across cellular membranes to acidify various organelles |
|
essential roles of ATP6V0A1 in neuronal development in terms of integrity and connectivity of neurons |
|
is a regulator of peripheral metabolic memory, providing a potential target for regulation of food intake, weight loss maintenance and the treatment of obesity |
|
is involved in the exocytosis pathway, especially in vesicular transport in neurons |
