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FLASH GENE
Symbol FPGS contributors: KTN/npt - updated : 04/12/2008
HGNC name folylpolyglutamate synthase
HGNC id 3824
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Lymphoid/Immunelymph node   moderately
 thymus   moderately
Reproductivefemale systemuteruscervix highly
 female systemovary  moderately
 male systemprostate  moderately
Skin/Tegumentskin   moderately
cell lineage
cell lines
fluid/secretion predominantly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N terminal 42 AA mitochondrial leader peptide
    • mono polymer monomer
    HOMOLOGY
    interspecies homolog to dog FPGS (86.9 pc)
    homolog to murine Fpgs (81.9 pc)
    Homologene
    FAMILY
  • folylpolyglutamate synthase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the conversion of folates to polyglutamate derivatives
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism cofactor
    signaling
    tetrahydrofolylpolyglutamate biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS