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FLASH GENE
Symbol AGFG1 contributors: mct - updated : 29-09-2007
HGNC name ArfGAP with FG repeats 1
HGNC id 5175
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Hrb
intraspecies homolog to nucleoporins
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,vesicle
intracellular,nucleus,nucleoplasm
intracellular,nuclear envelope,pore
text In the cytoplasm, colocalized with clathrin-, AP-2-, EPS15-, and transferrin receptor-containing vesicles (Chaineau 2008)
basic FUNCTION
  • activator for the HIV-1, mediating nucleocytoplasmic transport
  • facilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is required for viral replication
  • essential Rev cofactor that promotes the release of incompletely spliced HIV-1 RNAs from the perinuclear region
  • being an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm
  • involved in clathrin-dependent endocytosis and recruits VAMP7 in this process (Chaineau 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • REV interacting (binds the REV activation domain when REV is assembled onto its RNA target and can significantly enhance REV activity when overexpressed)
  • partner of the tyrosine kinase substrate EPS15 (Chaineau 2008)
  • partner of the vesicular SNARE tetanus neurotoxin-insensitive vesicle-associated membrane protein VAMP7 (Chaineau 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS