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FLASH GENE

Symbol

AGFG1

contributors: mct - updated : 29-09-2007

HGNC name	ArfGAP with FG repeats 1
HGNC id	5175

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 2800 - 562 ubiquitous Bogerd - - - 4600 - - ubiquitous Bogerd

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Hearing/Equilibrium ear inner cochlea   highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Hrb

intraspecies

homolog to nucleoporins

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus,nucleoplasm
	intracellular,nuclear envelope,pore
text	In the cytoplasm, colocalized with clathrin-, AP-2-, EPS15-, and transferrin receptor-containing vesicles (Chaineau 2008)

basic FUNCTION	activator for the HIV-1, mediating nucleocytoplasmic transport
	facilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is required for viral replication
	essential Rev cofactor that promotes the release of incompletely spliced HIV-1 RNAs from the perinuclear region
	being an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm
	involved in clathrin-dependent endocytosis and recruits VAMP7 in this process (Chaineau 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	REV interacting (binds the REV activation domain when REV is assembled onto its RNA target and can significantly enhance REV activity when overexpressed)
	partner of the tyrosine kinase substrate EPS15 (Chaineau 2008)
	partner of the vesicular SNARE tetanus neurotoxin-insensitive vesicle-associated membrane protein VAMP7 (Chaineau 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS