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FLASH GENE
Symbol AGFG1 contributors: mct - updated : 29-09-2007
HGNC name ArfGAP with FG repeats 1
HGNC id 5175
Location 2q36.3      Physical location : 228.336.887 - 228.425.938
Genatlas name nucleoporin-like protein RIP
Synonym name
  • Rev/Rex activation domain-binding (Rab) cofactor (hRIP)
  • Rab, Rev/Rex activation domain-binding protein
  • hRIP, Rev interacting protein
  • HIV-1 Rev binding protein
    • Synonym symbol(s) RAB, RIP, NUPL, MGC116938, MGC116940, HRB
    DNA
    TYPE like-sequence
    STRUCTURE 85.00 kb     13 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 2800 - 562 ubiquitous Bogerd
    - - - 4600 - - ubiquitous Bogerd
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Hearing/Equilibriumearinnercochlea highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Hrb
    intraspecies homolog to nucleoporins
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,pore
    text In the cytoplasm, colocalized with clathrin-, AP-2-, EPS15-, and transferrin receptor-containing vesicles (Chaineau 2008)
    basic FUNCTION
  • activator for the HIV-1, mediating nucleocytoplasmic transport
  • facilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is required for viral replication
  • essential Rev cofactor that promotes the release of incompletely spliced HIV-1 RNAs from the perinuclear region
  • being an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm
  • involved in clathrin-dependent endocytosis and recruits VAMP7 in this process (Chaineau 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • REV interacting (binds the REV activation domain when REV is assembled onto its RNA target and can significantly enhance REV activity when overexpressed)
  • partner of the tyrosine kinase substrate EPS15 (Chaineau 2008)
  • partner of the vesicular SNARE tetanus neurotoxin-insensitive vesicle-associated membrane protein VAMP7 (Chaineau 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS