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FLASH GENE
Symbol CRMP1 contributors: mct/npt - updated : 04-09-2018
HGNC name collapsin response mediator protein 1
HGNC id 2365
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amidohydrolase motif
    • mono polymer heteromer , polymer
    HOMOLOGY
    interspecies homolog to C.elegans unc-33
    intraspecies homolog to dihydropyrimidinase protein 1
    Homologene
    FAMILY
  • amidohydrolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • putatively involved in pyrimidine catabolism
  • neural growth cone collapse
  • suppressor of metastastic invasion
  • involved in invasion, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CRMP1 and DPYSL3 regulate likely proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
    • CELLULAR PROCESS nucleotide, chromatin organization
    PHYSIOLOGICAL PROCESS development
    text neurogenesis
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • complexing with dihydropyriminidase (DPYSLs)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p80-ROK-alpha associating with PPYSL2 and modulating RhoA-induced neuronal morphogenesis
  • interacting with GNE and ZBTB16
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS