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FLASH GENE

Symbol

CRMP1

contributors: mct/npt - updated : 04-09-2018

HGNC name	collapsin response mediator protein 1
HGNC id	2365

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	72.29 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CRMP1 or variant 2 14 - 3046 62.2 572 - Leung, Weidemann (2006) p80-ROK-alpha - - 6408 150.9 1388 - Leung variant 1 14 - 3155 - 686 - Weidemann (2006)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Nervous brain       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, neonatal

Text	brain, developing limb, ectoderm
	abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an amidohydrolase motif

mono polymer

heteromer , polymer

HOMOLOGY

interspecies

homolog to C.elegans unc-33

intraspecies

homolog to dihydropyrimidinase protein 1

Homologene

FAMILY

amidohydrolase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	putatively involved in pyrimidine catabolism
	neural growth cone collapse
	suppressor of metastastic invasion
	involved in invasion, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
	CRMP1 and DPYSL3 regulate likely proper orientation of the basal dendrites of layer V neurons in the cerebral cortex

CELLULAR PROCESS

nucleotide, chromatin organization

PHYSIOLOGICAL PROCESS

development

text	neurogenesis

PATHWAY

metabolism

purine/pyrimidine

signaling

a component

complexing with dihydropyriminidase (DPYSLs)

INTERACTION

DNA

RNA

small molecule

protein	p80-ROK-alpha associating with PPYSL2 and modulating RhoA-induced neuronal morphogenesis
	interacting with GNE and ZBTB16

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS