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FLASH GENE
Symbol RPS6KA2 contributors: mct - updated : 24-03-2012
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 2
HGNC id 10431
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
two non identical catalytic domains,respectively located in N and C terminal region
HOMOLOGY
Homologene
FAMILY growth factor regulated serine/threonine kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,ribosome
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • ribosomal S6 kinase,serine/threonine kinase,non receptor type,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors
  • maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
  • putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer
  • critical serine/threonine kinase for the regulation of cell transformation
  • key regulator for cell transformation induced by tumor promoters such as EGF and TPA
  • negatively regulates axon elongation via the MAPK pathway
  • important in diverse cellular processes including gene expression, cell proliferation, and survival
  • dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-ITD-induced hematopoietic transformation
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • interacting with MAPK7
  • binding to PDZ domain proteins and phosphorylation of these proteins or their binding partners regulates excitatory synaptic transmission
  • EXOC3 regulates NFKB1 transcriptional activity via the control of the phosphorylation of NFKBIA, RPS6KA2, and ERK
    • cell & other
    REGULATION
    Phosphorylated by MAPK7 (phosphorylation by MAPK7 causes its activation, indicating that RPS6KA2 is a substrate of MAPK7)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS