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FLASH GENE

Symbol

RPS6KA2

contributors: mct - updated : 24-03-2012

HGNC name	ribosomal protein S6 kinase, 90kDa, polypeptide 2
HGNC id	10431

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	452.92 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001006932 22 - 5735 NP_001006933 90 741 - 2011 21527514 NM_021135 21 - 5817 NP_066958 - 733 - 2011 21527514

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Reproductive female system ovary       Homo sapiens Respiratory lung       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Reproductive epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two non identical catalytic domains,respectively located in N and C terminal region

HOMOLOGY

Homologene

FAMILY

growth factor regulated serine/threonine kinase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm

basic FUNCTION	ribosomal S6 kinase,serine/threonine kinase,non receptor type,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors
	maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
	putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer
	critical serine/threonine kinase for the regulation of cell transformation
	key regulator for cell transformation induced by tumor promoters such as EGF and TPA
	negatively regulates axon elongation via the MAPK pathway
	important in diverse cellular processes including gene expression, cell proliferation, and survival
	dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-ITD-induced hematopoietic transformation

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule
	ATP binding

protein	RPS6 binding
	interacting with MAPK7
	binding to PDZ domain proteins and phosphorylation of these proteins or their binding partners regulates excitatory synaptic transmission
	EXOC3 regulates NFKB1 transcriptional activity via the control of the phosphorylation of NFKBIA, RPS6KA2, and ERK

cell & other

REGULATION

Phosphorylated by

MAPK7 (phosphorylation by MAPK7 causes its activation, indicating that RPS6KA2 is a substrate of MAPK7)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS