Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TNNT1 contributors: mct - updated : 03-04-2018
HGNC name troponin T type 1 (skeletal, slow)
HGNC id 11948
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
interspecies ortholog to murine Tnnt1
homolog to C.elegans C05D11.13
Homologene
FAMILY
  • troponin T family
    • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the attachment of the complex to tropomyosin and troponin I
  • regulating muscle contraction
  • sarcomeric thin filament anchoring subunit of the troponin complex in striated muscles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TPM3 and ACTA1
  • cardiac expression of TNNT1 strictly depends on the physical interaction between GATA4-ZFPM2 in the myocardium of both atria and ventricles
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • marker for cardiac remodeling in hypertrophic cardiomyopathy
    • Therapy target
    ANIMAL & CELL MODELS