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FLASH GENE
Symbol TNNT1 contributors: mct - updated : 03-04-2018
HGNC name troponin T type 1 (skeletal, slow)
HGNC id 11948
Corresponding disease
NEM5 nemaline myopathy 5
Location 19q13.42      Physical location : 55.644.161 - 55.660.606
Synonym name
  • skeletal muscle slow-twitch TnT
  • troponin T1, skeletal, slow
  • Synonym symbol(s) ANM, STNT, TNT, TNTS, FLJ98147, MGC104241, HSSTnT
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text upstream and in tandem with TNNT3
    STRUCTURE 16.66 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see NEM3
    Physical map
    LOC388562 19 similar to 1060P11.4.2 (killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (isoform 2) (KIR103-AS)) KIR3DL1 19q13.4 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 KIR2DS4 19q13.4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 FCAR 19q13.4 Fc fragment of IgA, receptor for NCR1 19q13.42 natural cytotoxicity triggering receptor 1 NALP7 19q13.42 NACHT, leucine rich repeat and PYD containing 7 NALP2 19q13.42 NACHT, leucine rich repeat and PYD containing 7 GP6 19q13.4 glycoprotein VI (platelet) RDH13 19q13.42 retinol dehydrogenase 13 (all-trans and 9-cis) EPS8L1 19q13.42 EPS8-like 1 PPP1R12C 19q13.42 protein phosphatase 1, regulatory (inhibitor) subunit 12C TNNT1 19q13.4 troponin T1, skeletal, slow TNNI3 19q13.4 troponin I, cardiac LOC352909 19q13.4 similar to hypothetical testis protein from macaque SYT5 19q13.4 synaptotagmin V PTPRH 19q13.4 protein tyrosine phosphatase, receptor type, H LOC388563 19 LOC388563 MGC30208 19q13.42 hypothetical protein MGC30208 KIAA1115 19q13.42 KIAA1115 HSPBP1 19q13.42 hsp70-interacting protein KIAA1811 19q13.4 KIAA1811 protein LOC284417 19q13.42 similar to BC022651 protein MGC2705 19q13.42 hypothetical protein MGC2705 COXVIB2 19q13.42 cytochrome c oxidase subunit VIb, testes-specific MGC35045 19q13.42 hypothetical protein MGC35045 IL11 19q13.4 interleukin 11 MDAC1 19q13.42 MDAC1 LOC388564 19 hypothetical gene supported by BC052596 RPL28 19q13.4 ribosomal protein L28
    RNA
    TRANSCRIPTS type messenger
    text has different isoforms produced by alternative splicing of the two exons located in two different domains (exon 5 located in the N terminus and exon 12 located in the C terminus)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 1178 30 251 - 2012 22977240
  • HSSTnT2
  • having exon 5, but not exon 12
  • 14 splicing 1211 31 262 - 2012 22977240
    14 splicing 1259 32.8 278 - 2012 22977240
  • HSSTnT1
  • having exons 5 and 12
  • may be more susceptible to calpain cleavage than the other HSSTnTs
  • 14 - 1273 - 251 - 2012 22977240
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivemouth   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal highly Homo sapiensAdult
    Muscularstriatumcardiac highly Homo sapiens
    Muscularstriatumskeletal   Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Tnnt1
    homolog to C.elegans C05D11.13
    Homologene
    FAMILY
  • troponin T family
  • CATEGORY motor/contractile , regulatory , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in the attachment of the complex to tropomyosin and troponin I
  • regulating muscle contraction
  • sarcomeric thin filament anchoring subunit of the troponin complex in striated muscles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text muscle development
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of the troponin complex forming the calcium-sensitive molecular switch that regulates striated muscle contraction in response to modifications in intracellular concentration
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to TPM3 and ACTA1
  • cardiac expression of TNNT1 strictly depends on the physical interaction between GATA4-ZFPM2 in the myocardium of both atria and ventricles
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • marker for cardiac remodeling in hypertrophic cardiomyopathy
  • Therapy target
    ANIMAL & CELL MODELS