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FLASH GENE

Symbol

RASGRF2

contributors: mct - updated : 24-06-2019

HGNC name	Ras protein-specific guanine nucleotide-releasing factor 2
HGNC id	9876

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral imprinting       frequent methylation and silencing in the carcinogenesis of non-small cell lung cancer (NSCLC)

Susceptibility

to alcoholic cirrhosis

Variant & Polymorphism SNP	A allele of the RASGRF2 polymorphism (rs26907) was significantly more prevalent among alcoholic patients with cirrhosis compared to alcoholic patients without alcoholic liver disease (ALD)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

ethanol intake and preference were decreased in Rasgrf2(-/-) mice relative to WT controls