basic FUNCTION
| functioning as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP |
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preferentially activating HRAS in vivo compared to RRAS based on their different types of prenylation |
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functioning in synaptic plasticity by contributing to the induction of long term potentiation |
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involved in T-cell receptor- and NF-AT-mediated immune responses |
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RASGRF1 and -GRF2 may act as adaptors that bind PLCG1 and restrict Ca2+ signalling to the vicinity of focal adhesions, indicating a new role for these GRFs that is required for IL1 induction of the RAS& |
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8594;ERK pathway and MMP3 expression |
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mediates Ca(2+)-dependent activation of the ERK pathway |
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role for RASGRF2 in the regulation of mesolimbic dopamine neuron activity, reward response, and alcohol use and abuse |
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RASGRF2 regulates both the basal level and environmentally induced increase of newborn neuron survival, as well as in the induction of a distinct form of synaptic plasticity of newborn neurons that contributes to distinct features of hippocampus-derived learning and memory |
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is a calcium sensor and MAPK/ERK activating protein, which has been linked to neurotransmitter release and monoaminergic receptor adaptations |
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controls likely dopaminergic signalling and adaptations to alcohol also in other brain regions, beyond the nucleus accumbens |
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functional role uncovered for RASGRF2 in control of nuclear migration in cone photoreceptors during postnatal retinal development |