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FLASH GENE

Symbol

TCN1

contributors: - updated : 16-03-2006

HGNC name	transcobalamin I (vitamin B12 binding protein, R binder family)
HGNC id	11652

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q11-q12      Physical location : 59.620.280 - 59.634.041
Synonym name	haptocorrin
Synonym symbol(s)	TC1, TCI

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland           stomach       highly Endocrine pancreas       moderately   parathyroid       moderately Reproductive female system breast mammary gland   moderately   male system prostate     moderately Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil

cell lineage
cell lines
fluid/secretion	milk, saliva, tears, bile, plasma

at STAGE

physiological period

Text	later stages of myeloid development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a signal peptide

conjugated

GlycoP

isoforms

Precursor

a signal peptide from the 1st to the 23th aa

HOMOLOGY

Homologene

FAMILY	vitamin B12-binding protein family
	eukaryotic cobalamin transport protein family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
text	secreted, secondary granules

basic FUNCTION

facilitating the transport of cobalamin into cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

exocytosis transport , cellular trafficking transport

text	cobalamin transport

PATHWAY

metabolism

signaling

a component

major constituent ofsecondary granules in neutrophils

INTERACTION

DNA

RNA

small molecule	metal binding,
	ion Co2+

protein

cell & other

vitamin B12

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS