Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DGUOK contributors: - updated : 11-04-2007
HGNC name deoxyguanosine kinase
HGNC id 2858
Corresponding disease
MDDS1 mitochondrial DNA depletion syndrome, hepatocerebral form
Location 2p13      Physical location : 74.153.952 - 74.186.086
Synonym name deoxyguanosine kinase, mitochondrial
Synonym symbol(s) DGK
EC.number 2.7.1.113
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391387 2 similar to protein 40kD ALMS1 2p13 Alstrom syndrome 1 NAT8 2p13-1-p12 N-acetyltransferase 8 (camello like) LOC200420 2p13.1 LOC200420 CML2 2p13.1 putative N-acetyltransferase Camello 2 CGI-121 2p24.3-p24.1 CGI-121 protein DUSP11 2p13 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) LOC388960 2 similar to hypothetical protein 4921507A12 AMSH ACTG2 2p13.1 actin, gamma 2, smooth muscle, enteric DGUOK 2p24.3-p24.1 deoxyguanosine kinase LOC388961 2 LOC388961 MGC22014 2p13.1 hypothetical protein MGC22014 MGC10955 2p13.1 hypothetical protein MGC10955 LOC388962 2 similar to RIKEN cDNA 1810056O20 C2orf6 2p12 chromosome 2 open reading frame 6 MTHFD2 2p12 methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase SLC4A5 2p13 solute carrier family 4, sodium bicarbonate cotransporter, member 5 DCTN1 2p13 dynactin 1 (p150, glued homolog, Drosophila) LOC388963 2 similar to Retinol dehydrogenase 12 LOC257200 2p13.1 similar to high mobility group AT-hook 1 FLJ12953 2p13.1 hypothetical protein FLJ12953 similar to Mus musculus D3Mm3e RTKN 2p13 rhotekin
RNA
TRANSCRIPTS type messenger
text five variants, four isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1144 32 277 - Johansson
- splicing 880 - 189 - Johansson
same reading frame as variant 1
- splicing 1031 - 89 - Johansson
truncated
- splicing 767 - 89 neurons of the olfactory bulb, hippocampus , and cerebral and cerebellar cortex Johansson, Hozumi
  • truncated, nuclear
  • four ankyrin-like repeats and a nuclear localization signal (NLS)
  • - - 1117 - 63 - Johansson
    unique C terminus
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal mitochondrial targeting signal
  • a deoxyguanosine kinase domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Dguok
    intraspecies homolog to DCK
    Homologene
    FAMILY DCK/DGK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • phosphorylation of purine deoxyribonucleotides and of analogs used in the treatment of lymphoproliferative disorders
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MDDS1
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS