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FLASH GENE
Symbol TTC3 contributors: mct/npt - updated : 20-05-2009
HGNC name tetratricopeptide repeat domain 3
HGNC id 12393
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal protein phosphatase domain
  • a coiled coil region within the TPR made of three tetratricopeptide repeats near in the C terminal region
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • inhibits neuronal differentiation via RhoA and Citron kinase (Berto 2007)
  • polyubiquitin binding protein involved in NF-kappaB signaling (Fenner 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TTC3-RhoA-CIT-K pathway that could be a crucial determinant of neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program (Berto 2007)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with Citron kinase (CIT-K) and Citron N (CIT-N), two effectors of the RhoA small GTPase that have previously been involved in neuronal proliferation and differentiation (Berto 2007)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS