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FLASH GENE

Symbol

PPP1R11

contributors: mct/ - updated : 24-09-2015

HGNC name	protein phosphatase 1, regulatory (inhibitor) subunit 11
HGNC id	9285

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.18 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see HFEC@

regionally located

. belonging to a cluster of genes in the MHC1 region (see HFEC@), 150 kb centrometric to the HLA-A gene

RNA

TRANSCRIPTS	type	messenger

text	existence of the least 1 spliced form (PMID: 8938444)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_021959 3 - 1664 NP_068778 - 126 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

tissues

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	eight potential phosphorylation sites
	a C terminal PEST pattern
	a VxW motif

HOMOLOGY

interspecies

homolog to murine Tctex 5/Ppp1r11

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

basic FUNCTION

protein phosphatase inhibitor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	t complex associated
	PPP1R7 is kept in solution by formation of a ternary complex with PP1 and PPP1R11

INTERACTION

DNA

RNA

small molecule

protein

reciprocal relationship between the levels of the PPP1CC and its regulator PPP1R11, suggesing that complex formation between these polypeptides in testis may prevent proteolysis of PPP1R11 and thus, germ cell apoptosis

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS