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FLASH GENE
Symbol PPP1R11 contributors: mct/ - updated : 24-09-2015
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 11
HGNC id 9285
Location 6p22.1      Physical location : 1.275.162 - 30.038.106
Synonym name
  • hemochromatosis candidate gene V
  • t-complex-associated-testis-expressed 5
  • protein phosphatase inhibitor 3
  • inhibitor-3
    • Synonym symbol(s) HCG-V, TCTE5, HCGV, Tctex5, IPP3, MGC125741, MGC125742, MGC125743, I3
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 3.18 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map see HFEC@
    regionally located . belonging to a cluster of genes in the MHC1 region (see HFEC@), 150 kb centrometric to the HLA-A gene
    RNA
    TRANSCRIPTS type messenger
    text existence of the least 1 spliced form (PMID: 8938444)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1664 - 126 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • eight potential phosphorylation sites
  • a C terminal PEST pattern
  • a VxW motif
    • HOMOLOGY
    interspecies homolog to murine Tctex 5/Ppp1r11
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • protein phosphatase inhibitor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • t complex associated
  • PPP1R7 is kept in solution by formation of a ternary complex with PP1 and PPP1R11
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • reciprocal relationship between the levels of the PPP1CC and its regulator PPP1R11, suggesing that complex formation between these polypeptides in testis may prevent proteolysis of PPP1R11 and thus, germ cell apoptosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS