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FLASH GENE
Symbol CCRL2 contributors: mct - updated : 21-10-2013
HGNC name chemokine (C-C motif) receptor-like 2
HGNC id 1612
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
HOMOLOGY
intraspecies homolog to CCR1
Homologene
FAMILY G protein coupled receptor family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • functional receptor that may be involved in the pathogenesis of rheumatoid arthritis
  • link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1
  • nonredundant role of CCRL2 in lung dendritic cells trafficking and potential role for this receptor in the control of excessive airway inflammatory responses
  • G protein-coupled receptor which plays a key role in lung dendritic cell trafficking to peripheral lymph nodes
    • CELLULAR PROCESS cell communication
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • chemerin (RARRES2) is a natural nonsignaling protein ligand for CCRL2
  • chemokine CCL19 is a specific ligand for CCRL2 (CCL19 is known to be critically involved in lymphocyte and dendritic cell trafficking, and CCL19-binding competition by CCRL2 might be involved in modulating these processes)
  • chemokine CCL5 and CCL19 are reported to bind to CCRL2
  • chemerin, a ligand for CMKLR1, is a ligand for CCRL2 (CCRL2 binds chemerin and increases local chemerin concentration to efficiently present it to CMKLR1 on nearby cells, providing a link between CCRL2 and CMKLR1)
  • RARRES2 is a protein ligand for the G protein-coupled receptor CMKLR1 and also binds to two atypical heptahelical receptors, CCRL2 and GPR1
    • cell & other
    REGULATION
    Other upregulated on neutrophil activation and during monocyte to macrophage differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    on synovial neutrophils of rheumatoid arthritis patients
    tumoral     --over  
    in glioma promotes cell migration and invasion
    Susceptibility to rheumatoid arthritis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • CCRL2(-/-) mice showed normal recruitment of circulating DC into the lung, but a defective trafficking of antigen-loaded lung dendritic cells to mediastinal lymph nodes