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FLASH GENE

Symbol

RGL2

contributors: mct - updated : 22-09-2015

HGNC name	ral guanine nucleotide dissociation stimulator-like 2
HGNC id	9769

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one N-terminal Ras-GEF domain
	one Ras-biding domain (RBD)
	one Ras-GEF domain
	a putative PRKACA (protein kinase A) phosphorylation site at the C-terminal of the domain that regulates the interaction with small GTPases

HOMOLOGY

interspecies	ortholog to murine Rgl2
	homolog to rattus Rab2l

intraspecies

homolog to Ral guanine nucleotide dissociation stimulator (RALGDS)

Homologene

FAMILY	GTP binding protein family
	RalGDS family

CATEGORY

protooncogene , signaling , transport

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	guanine nucleotide dissociation stimulator, potential effector for Ras and Rap1 proteins
	RGL2 and RALA, RALB are important previously unrecognized signaling components that regulate transcriptional responses in myocardial cells
	has guanine-nucleotide-exchange activity toward the small GTPase RALA
	with RALGDS and RGL3, can interact with activated Ras through their Ras Binding Domain (RBD), but may function as effectors for other Ras family members
	crucial role in coupling activated Ras to activation of RAL, thus regulating several fundamental cell processes
	modulates expression of hypertrophic genes in cardiomyocytes
	RGL2 upregulation in hypertrophic hearts may be a protective mechanism

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	vesicular traffick

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to the GTP-bound form of RAP1
	potential effector for RAS and the RAS analogue RAP1B
	RAB10 recruits RGL2 to membrane compartments for RALA activation and RALA is downstream of RAB10

cell & other

REGULATION

Phosphorylated by

PRKACA (phosphorylated by PRKACA and phosphorylation reduces the ability of RGL2 to bind HRAS)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in cardiomyocytes promotes activation of the PI3-kinase signaling cascade and protects from carciomyocyte death and pathologic cardiac fibrosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular aquired heart failure may be a novel therapeutic target in treating heart disease

ANIMAL & CELL MODELS