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FLASH GENE
Symbol RGL2 contributors: mct - updated : 22-09-2015
HGNC name ral guanine nucleotide dissociation stimulator-like 2
HGNC id 9769
Location 6p21.32      Physical location : 4.491.674 - 33.267.176
Synonym name
  • RAB2, member RAS oncogene family-like
  • RalGDS-like factor
  • RAS-associated protein RAB2L
  • RalGDS-like 2
  • GDS-related protein
    • Synonym symbol(s) RAB2L, RALGDS2, KE1.5, HKE1.5, RLF
    DNA
    TYPE functioning gene
    STRUCTURE 7.79 kb     18 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 3425 - 777 - 1996 8939933
    17 - 3165 - 695 - 1996 8939933
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one N-terminal Ras-GEF domain
  • one Ras-biding domain (RBD)
  • one Ras-GEF domain
  • a putative PRKACA (protein kinase A) phosphorylation site at the C-terminal of the domain that regulates the interaction with small GTPases
    • HOMOLOGY
    interspecies ortholog to murine Rgl2
    homolog to rattus Rab2l
    intraspecies homolog to Ral guanine nucleotide dissociation stimulator (RALGDS)
    Homologene
    FAMILY
  • GTP binding protein family
  • RalGDS family
    • CATEGORY protooncogene , signaling , transport
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • guanine nucleotide dissociation stimulator, potential effector for Ras and Rap1 proteins
  • RGL2 and RALA, RALB are important previously unrecognized signaling components that regulate transcriptional responses in myocardial cells
  • has guanine-nucleotide-exchange activity toward the small GTPase RALA
  • with RALGDS and RGL3, can interact with activated Ras through their Ras Binding Domain (RBD), but may function as effectors for other Ras family members
  • crucial role in coupling activated Ras to activation of RAL, thus regulating several fundamental cell processes
  • modulates expression of hypertrophic genes in cardiomyocytes
  • RGL2 upregulation in hypertrophic hearts may be a protective mechanism
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular traffick
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the GTP-bound form of RAP1
  • potential effector for RAS and the RAS analogue RAP1B
  • RAB10 recruits RGL2 to membrane compartments for RALA activation and RALA is downstream of RAB10
    • cell & other
    REGULATION
    Phosphorylated by PRKACA (phosphorylated by PRKACA and phosphorylation reduces the ability of RGL2 to bind HRAS)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in cardiomyocytes promotes activation of the PI3-kinase signaling cascade and protects from carciomyocyte death and pathologic cardiac fibrosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquiredheart failure
    may be a novel therapeutic target in treating heart disease
    ANIMAL & CELL MODELS