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FLASH GENE

Symbol

RPSA

contributors: mct - updated : 02-04-2014

HGNC name	ribosomal protein SA
HGNC id	6505

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	region between AAs 236-262 is required for binding to 40S ribosomal subunits
	a eukaryote-specific C-terminal domain (CTD) that is responsible in RPSA for the binding of laminin as well as prions and several viruses , and ability of RPSA to regulate viability is associated with its C-terminal 75 AAs but this function is distinct from its role in cell proliferation, independent of its ribosomal functions, and may be regulated by a nonnuclear localization

isoforms

Precursor

precursor of the cell-surface laminin receptor, LAMR (RPSA)

HOMOLOGY

interspecies

homolog to murine Lamr1

Homologene

FAMILY

ribosomal protein S2P family

CATEGORY

adhesion , signaling , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus

basic FUNCTION	involved in translational machinery
	playing a major role in tumor aggressiveness and metastasis
	promotes CNF1-expressing E. coli K1 internalization of human brain microvascular endothelial cells
	multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly
	non integrin cell surface receptor for the extracellular matrix whose expression is increased in neoplastic cells and directly correlates with an enhanced invasive and metastatic potential
	role in cancer and infection diseases
	functions as a cancer-specific death receptor
	essential role for RPSA in human spleen development

CELLULAR PROCESS	protein, translation/synthesis
	protein, translation regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

component of the small subunit of the ribosome

INTERACTION

DNA

RNA

small molecule

protein	PRP (prion protein)-receptor for cellular PRP on the surface of cells
	CTSB (increasing the laminin degradation rate and releasing motility fragments)
	targeting PPYR1 (LAMR1 is a PPP1R16B-dependent PPYR1 substrate)
	upon TCR plus integrin costimulation, SH2D2A associates with RPSA and mediates T lymphocyte migration
	molecular interaction of PEA15 with RPSA (PEA15 ability to induce cell responses to ECM-derived signals through interaction with RPSA may be of crucial importance for tumour cell survival in a poor microenvironment, thus favouring the metastatic spread and colonization)

cell & other

associating with the ribosome

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICAS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   higher in colon carcinoma tissue, urothelial tumors and lung cancer cell line than their normal counterparts

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     PDE5A inhibitors could be used to elevate cGMP levels to induce RPSA-mediated, cancer-specific cell death

ANIMAL & CELL MODELS